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Since the end of 2012, a new interdisciplinary research project has been devoted to fourteenth to sixteenth-century Florentine paintings. The project will allow insights into the technological development of Florentine painting. At the same time, it encompasses one of the internationally most important collections of the Alte Pinakothek: for the first time, a complex of more than 80 works from the centre of the Italian Renaissance is being systematically investigated. Among them are paintings by Giotto, Fra Angelico, Sandro Botticelli and Leonardo da Vinci, some of the leading masters in the history of European art.

An interdisciplinary team are using cutting-edge art-historical, art-technological and scientific methods not only to examine stylistic or iconographic aspects, but also, in the same way, to analyse the processes by which these works were created. The Doerner Institut is using technical photography including radiography and digital infrared reflectography , supplemented by pigment and media analysis.